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Po Wu Gean

Researcher at National Cheng Kung University

Publications -  123
Citations -  11262

Po Wu Gean is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Excitatory postsynaptic potential & Long-term potentiation. The author has an hindex of 44, co-authored 120 publications receiving 10357 citations. Previous affiliations of Po Wu Gean include National Institute on Drug Abuse.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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A Role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

Chih Hung Lin, +6 more
- 13 Sep 2001 - 
TL;DR: Western blot analysis of neuronal tissues taken from fear-conditioned rats showed a selective activation of phosphatidylinositol 3-kinase (PI-3 kinase) in the amygdala, and this activation may occur at a point upstream of MAPK activation.
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Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

Po See Chen, +13 more
- 01 Dec 2006 - 
TL;DR: Astrocyte is identified as a novel target for VPA to induce neurotrophic and neuroprotective actions in rat midbrain and shows a potential new role of cellular interactions between DA neurons and astrocytes.
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The Similarities and Diversities of Signal Pathways Leading to Consolidation of Conditioning and Consolidation of Extinction of Fear Memory

Chih-Hung Lin, +3 more
- 10 Sep 2003 - 
TL;DR: It is shown for the first time that an intra-amygdala injection of transcription inhibitor actinomycin D at the dose that blocked acquisition failed to affect extinction of a learned response and protein synthesis inhibitor anisomycin blocked both acquisition and extinction.
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Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity.

Po See Chen, +11 more
- 12 Oct 2007 - 
TL;DR: It is found that VPA induced apoptosis of microglia cells in a time- and concentration-dependent manner and the potential utility of HDACIs in preventing inflammation-related neurodegenerative disorders such as Parkinson's disease is underscored.