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Umesh K. Jinwal

Researcher at University of South Florida

Publications -  70
Citations -  8841

Umesh K. Jinwal is an academic researcher from University of South Florida. The author has contributed to research in topics: Tau protein & Heat shock protein. The author has an hindex of 34, co-authored 70 publications receiving 8004 citations. Previous affiliations of Umesh K. Jinwal include University of Michigan & University of Arkansas for Medical Sciences.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

Umesh K. Jinwal, +14 more
- 30 Sep 2009 - 
TL;DR: It is found that inhibiting Hsp70 ATPase activity after increasing its expression levels facilitated tau degradation at lower doses, suggesting that the authors can combine genetic and pharmacologic manipulation of HSp70 to control the fate of bound substrates.
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Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

Jose F. Abisambra, +15 more
- 29 May 2013 - 
TL;DR: It is suggested that soluble tau impairs ERAD and the result is activation of the unfolded protein response (UPR), and the reversibility of this process suggests that tau-based therapeutics could significantly delay this type of cell death and therefore disease progression.
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Akt and CHIP coregulate tau degradation through coordinated interactions.

Chad A. Dickey, +15 more
- 04 Mar 2008 - 
TL;DR: Akt serves as a major regulator of tau biology by manipulating both tau kinases and protein quality control, providing a link to several common pathways that have demonstrated dysfunction in Alzheimer's disease.
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The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Umesh K. Jinwal, +13 more
- 13 Jan 2010 - 
TL;DR: It is proposed that FKBP51 can use the Hsp90 complex to isomerize tau, altering its phosphorylation pattern and stabilizing microtubules in a reaction depending on the PPIase activity of FK BP51.