Sara W. Bird

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.

TL;DR: In this article, the authors used quantitative time-lapse microscopy to show the spread of infectious cytoplasmic material between cells in the absence of lysis, and showed that pharmacological stimulation of the autophagy pathway caused more rapid viral spread in tissue culture and greater pathogenicity in mice.

TL;DR: Comparing how RNA viruses manipulate the autophagy pathway reveals new noncanonical autophagic routes, explains the exacerbation of disease by starvation, and uncovers common targets for antiviral drugs.