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Zhi-Xiang Xu

Researcher at Jilin University

Publications -  76
Citations -  8826

Zhi-Xiang Xu is an academic researcher from Jilin University. The author has contributed to research in topics: Apoptosis & Autophagy. The author has an hindex of 31, co-authored 65 publications receiving 7748 citations. Previous affiliations of Zhi-Xiang Xu include University of Texas MD Anderson Cancer Center & University of Alabama at Birmingham.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The Energy Sensing LKB1-AMPK Pathway Regulates p27kip1 Phosphorylation Mediating the Decision to Enter Autophagy or Apoptosis

Jiyong Liang, +12 more
- 01 Feb 2007 - 
TL;DR: LKB1–AMPK pathway-dependent phosphorylation of p27 at Thr 198 stabilizes p27 and permits cells to survive growth factor withdrawal and metabolic stress through autophagy, which may contribute to tumour-cell survival under conditions of growth factor deprivation, disrupted nutrient and energy metabolism, or during stress of chemotherapy.
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BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly

Shiaw Yih Lin, +5 more
- 18 Oct 2005 - 
TL;DR: It is proposed that the microcephaly observed in patients with MCPH1 deficiencies is due to disruption of the ATR-BRCA1-Chk1 signaling pathway that is also disrupted in Seckel syndrome patients.
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PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1

Zhi-Xiang Xu, +3 more
- 15 Jun 2003 - 
TL;DR: PML regulates TopBP1 functions by association and stabilization of the protein in response to IR-induced DNA damage, and Pulse-chase labeling analysis demonstrated that PML overexpression stabilized the Top BP1 protein.
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Palmitoylation-dependent activation of MC1R prevents melanomagenesis.

Shuyang Chen, +16 more
- 21 Sep 2017 - 
TL;DR: It is shown that pharmacological activation of palmitoylation rescues the defects of Mc1r RHC variants and prevents melanomagenesis, highlighting a central role for MC1R palmitoyslation in pigmentation and protection against melanoma.