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Maximiliano G. Gutierrez

Researcher at Francis Crick Institute

Publications -  97
Citations -  12797

Maximiliano G. Gutierrez is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Phagosome & Mycobacterium tuberculosis. The author has an hindex of 35, co-authored 89 publications receiving 10993 citations. Previous affiliations of Maximiliano G. Gutierrez include National Institute for Medical Research & National University of Cuyo.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

TL;DR: It is demonstrated that autophagic pathways can overcome the trafficking block imposed by M. tuberculosis, which is a hormonally, developmentally, and immunologically regulated process, represents an underapp appreciated innate defense mechanism for control of intracellular pathogens.
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Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

TL;DR: It is found that neutrophils sensed microbe size and selectively released neutrophil extracellular traps (NETs) in response to large pathogens, such as Candida albicans hyphae andextracellular aggregates of Mycobacterium bovis, but not inresponse to small yeast or single bacteria.
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Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

TL;DR: Results indicate that a functional Rab7 is important for the normal progression of autophagy.
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Autophagy induction favours the generation and maturation of the Coxiella‐replicative vacuoles

TL;DR: The results suggest that transit through the autophagic pathway increases the infection with Coxiella by providing a niche more favourable to their initial survival and multiplication.