Marta Palmieri

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.

TL;DR: A potent anti-tumour activity of TSA/GEM combination against pancreatic cancer cells in vitro and in vivo is demonstrated, strongly supporting the use of GEM in combination with an HDAC inhibitor for pancreaticcancer therapy.

TL;DR: Novel findings concerning events that can occur in a concerted manner at various levels of UCP2 regulation are described: Ucp2 gene mutation (single nucleotide polymorphisms), U CP2 mRNA and protein expression (transcriptional, translational, and protein turn-over regulation), UCP1 proton conductance (ligands and post-transcriptionAL modifications), and nutritional and pharmacological regulation of U CP1.

TL;DR: The results demonstrate the specificity of C12GEM targeting toward CD44-overexpressing pancreatic adenocarcinoma cell line using HA as a ligand and the cytotoxicity of the different preparations was evaluated.