Jeff Kuret

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The results suggest that tau adopts a distinct conformation when polymerized into filaments and that this conformation is recognized selectively by Alz50.

TL;DR: Results suggest that only part of the microtubule-binding domain (repeats 1, 2 and a small portion of 3) is crucial for tau polymerization, and the C terminus of tau clearly inhibits the assembly process.

TL;DR: Direct interactions among tau, PP2A, and MTs at the submolecular level are described, indicating how structural interactions among ABαC, t Tau, andMTs might control the phosphorylation state of tau.

TL;DR: Structural features required for the fatty acid class of tau fibrillization inducer are characterized using recombinant full-length tau protein, arachidonic acid, and a series of straight chain anionic, cationic, and nonionic detergents, suggesting anionic membranes may serve this function in vivo.