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Shoji Notomi

Researcher at Massachusetts Eye and Ear Infirmary

Publications -  23
Citations -  5793

Shoji Notomi is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Retinal pigment epithelium & Medicine. The author has an hindex of 12, co-authored 17 publications receiving 5181 citations. Previous affiliations of Shoji Notomi include Saga University & Kyushu University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Photoreceptor cell death and rescue in retinal detachment and degenerations.

TL;DR: A body of studies indicate that not only apoptotic but also autophagic and necrotic signaling are involved in photoreceptor cell death, and that combined targeting of these pathways may be an effective neuroprotective strategy for retinal diseases associated with photorecept cell loss.
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Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death

TL;DR: It is demonstrated that patients with photoreceptor injury by retinal detachment have increased levels of cleaved IL-1β, an end product of inflammasome activation, and a novel therapeutic target for treatment of retinal diseases is suggested.
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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky, +2522 more
- 01 Jan 2016 - 
TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis
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Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity

TL;DR: It is shown that Verteporfin-induced HMWC require the presence of light and the mechanism of this cross-linking, which involves both singlet oxygen and radical generation, can occur very efficiently even after lysis of the cells, if the lysate is not protected from ambient light.