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Sonia Rocha

Researcher at University of Liverpool

Publications -  110
Citations -  12271

Sonia Rocha is an academic researcher from University of Liverpool. The author has contributed to research in topics: Hypoxia-inducible factors & Transcription factor. The author has an hindex of 43, co-authored 98 publications receiving 10765 citations. Previous affiliations of Sonia Rocha include University of Dundee & ETH Zurich.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Regulation of hypoxia-inducible factor-1α by NF-κB

TL;DR: In this paper, the authors demonstrate that NF-κB (nuclear factor κB) is a direct modulator of HIF-1α expression and that HIF1α promoter is responsive to selective NFκB subunits.
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Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

TL;DR: It is demonstrated that NF-kappa B induced by cytotoxic stimuli, such as ultraviolet light and the chemotherapeutic drugs daunorubicin/doxorubsicin, is functionally distinct to that seen with the inflammatory cytokine TNF and is an active repressor of antiapoptotic gene expression.
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NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

TL;DR: It is reported that NF-κB organizes energy metabolism networks by controlling the balance between the utilization of glycolysis and mitochondrial respiration and establishes a role for NF-B in metabolic adaptation in normal cells and cancer.
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Ceramide Induces Cytochrome c Release from Isolated Mitochondria IMPORTANCE OF MITOCHONDRIAL REDOX STATE

TL;DR: It is concluded that the apoptogenic properties of ceramides are in part mediated via their interaction with mitochondrial cytoc followed by its release and that the redox state of cytoc influences its detachment by ceramide from the inner mitochondrial membrane.