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Sreejayan Nair

Researcher at University of Wyoming

Publications -  61
Citations -  7247

Sreejayan Nair is an academic researcher from University of Wyoming. The author has contributed to research in topics: Autophagy & Insulin resistance. The author has an hindex of 24, co-authored 53 publications receiving 6562 citations. Previous affiliations of Sreejayan Nair include New York Medical College & College of Health Sciences, Bahrain.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

Ulrich Bogdahn, +16 more
- 01 Jan 2011 - 
TL;DR: In this article, the authors evaluated the efficacy and safety of trabedersen (AP 12009) administered intratumorally by convection-enhanced delivery compared with standard chemotherapy in patients with recurrent/refractory high-grade glioma.
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Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation

Xihui Xu, +4 more
- 01 Feb 2013 - 
TL;DR: The present study evaluated the role of autophagy and Autophagy flux in HFD feeding-induced cardiac geometric and functional changes with a special focus on Akt2 signaling and found that an HFD-activated Akt and mTORC1 in the heart were mitigated by Akt 2 knockout.
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Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction.

Asli F. Ceylan-Isik, +6 more
- 01 Oct 2013 - 
TL;DR: Oral glucose tolerance test, echocardiography, cardiomyocyte contractile and intracellular Ca(2+) properties, and microRNAs which were elevated following high-fat feeding were attenuated by apelin treatment, suggesting a therapeutic potential of apelin in the management of cardiac dysfunction associated with obesity.
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Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications.

Yinan Hua, +1 more
- 01 Feb 2015 - 
TL;DR: A better understanding of the role of MMPs, cathepsins, calpain, calpains and caspases in cardiometabolic diseases process may yield novel therapeutic targets for treating or controlling these diseases.