Basil J. Petrof

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that dystrophin-deficient muscle fibers of the mdx mouse exhibit an increased susceptibility to contraction-induced sarcolemmal rupture, which strongly support the proposition that the primary function of dyStrophin is to provide mechanical reinforcement to the sarcolemma and thereby protect it from the membrane stresses developed during muscle contraction.

TL;DR: It is proposed that dystrophin deficiency alters the threshold for work-induced injury and provides a quantitative framework for studying the pathogenesis of dystrophy and extend the application of the mdx mouse as an animal model.

TL;DR: Diaphragmatic weakness, injury, and atrophy occur rapidly in critically ill patients during MV, and are significantly correlated with the duration of ventilator support.

TL;DR: This Critical Care Perspective defines the phenomenon, henceforth referred to as ventilatorinduced diaphragmatic dysfunction (VIDD), as a loss of diaphRAGmatic force-generating capacity that is specifically related to the use of mechanical ventilation.