Stephanie E. Wohlgemuth

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mt DNA mutations and display features of accelerated aging, suggesting that accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.

TL;DR: It is concluded that mild CR attenuates the age-related impairment of autophagy in rodent skeletal muscle, which might be one of the mechanisms by which CR attenuated age- related cellular damage and cell death in skeletal muscle in vivo.

TL;DR: It is suggested that aging in skeletal muscle is associated with impaired mitochondrial function and altered biogenesis pathways and that this may contribute to muscle atrophy and the decline in muscle performance observed in the elderly population.

TL;DR: This review discusses how factors common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy and describes gaps in the literature concerning the role of these factors in accelerating sarcopenia progression.