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Ubaldo E. Martinez-Outschoorn

Researcher at Thomas Jefferson University

Publications -  135
Citations -  19061

Ubaldo E. Martinez-Outschoorn is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cancer cell & Stromal cell. The author has an hindex of 61, co-authored 119 publications receiving 16562 citations. Previous affiliations of Ubaldo E. Martinez-Outschoorn include Thomas Jefferson University Hospital & National and Kapodistrian University of Athens.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

TL;DR: In this alternative model of tumorigenesis, the epithelial cancer cells instruct the normal stroma to transform into a wound-healing stroma, providing the necessary energy-rich micro-environment for facilitating tumor growth and angiogenesis, explaining its powerful predictive value.
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Cancer metabolism: a therapeutic perspective

TL;DR: How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.
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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

TL;DR: It is concluded that ketones and lactate fuel tumor growth and metastasis, providing functional evidence to support the "Reverse Warburg Effect" and may explain why diabetic patients have an increased incidence of cancer.