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Takehiko Matsushita

Researcher at Kobe University

Publications -  268
Citations -  10251

Takehiko Matsushita is an academic researcher from Kobe University. The author has contributed to research in topics: Anterior cruciate ligament & Medicine. The author has an hindex of 33, co-authored 223 publications receiving 8748 citations. Previous affiliations of Takehiko Matsushita include Case Western Reserve University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.

Kazunari Ishida, +12 more
- 21 Jan 2011 - 
TL;DR: The results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA, which was significantly suppressed in the TXA group compared to the control group.
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Autophagy modulates osteoarthritis-related gene expression in human chondrocytes.

Hiroshi Sasaki, +9 more
- 01 Jun 2012 - 
TL;DR: Increased autophagy was increased in OA chondrocytes and cartilage, and it was suggested that increased Autophagy is an adaptive response to protect cells from stresses, and that autophile regulates OA-like gene expression changes through the modulation of apoptosis and ROS.
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Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis.

Takehiko Matsushita, +5 more
- 01 Nov 2009 - 
TL;DR: The authors showed that inactivation of ERK1 and ERK2 in osteo-chondroprogenitor cells causes a block in osteoblast differentiation and leads to ectopic chondrogenic differentiation in the bone-forming region in the perichondrium.
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SIRT1 regulation of apoptosis of human chondrocytes.

Koji Takayama, +11 more
- 01 Sep 2009 - 
TL;DR: Results indicate that SIRT1 regulates apoptosis in human chondrocytes through the modulation of mitochondria-related apoptotic signals.