Amanda S. Bess

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The fields of environmental toxicology and environmental health should focus more strongly on mitochondria, with a particular focus on those toxicants that target mitochondrial DNA.

TL;DR: It is reported that removal of persistent mt DNA damage is detectable by 48 h in Caenorhabditis elegans, and requires mitochondrial fusion, fission and autophagy, providing genetic evidence for a novel mtDNA damage removal pathway.

TL;DR: This chapter was written as a guide to using the long-amplicon quantitative PCR (QPCR) assay for the measurement of DNA damage in mammalian as well as nonmammalian species such as Caenorhabditis elegans, Drosophila melanogaster, and two species of fish.