Kamal Chowdhury

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that Ambra1 (activating molecule in Beclin1-regulated autophagy), a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulatesAutophagy and has a crucial role in embryogenesis, and provides in vivo evidence supporting the existence of a complex interplay between autphagy, cell growth and cell death required for neural development in mammals.

TL;DR: It is proposed that the early expression of Pax4 in a subset of endocrine progenitors is essential for the differentiation of the β and δ cell lineages, and a default pathway would explain the elevated number of α cells in the absence of Pax 4.

TL;DR: It is concluded that both Pax genes are required for endocrine fate in the pancreas after showing that the paired-box gene Pax6 is expressed during the early stages of pancreatic development and in mature endocrine cells.

TL;DR: The complementary DNA cloning of the mouse Oct-4 gene is reported, and the characterization of the encoded protein(s) by sequential in vitro transcription, translation, DNA-binding and protease-clipping analysis shows thatOct-4 is a novel member of the POU-family.