Jae Keun Lee

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that genetic deficiency of mammalian sterile 20-like kinase 1 (MST1) delays disease onset and extends survival in mice expressing the ALS-associated G93A mutant of human SOD1.

TL;DR: The dysregulation of autophagy associated with ALS is summarized as well as potential therapeutic strategies based on modulation of the autophagic process.

TL;DR: It is shown that, by targeting apoptosis signal-regulating kinase 1 (ASK1), CIB1 negatively regulates stress-activated MAPK signaling pathways and functions as a Ca2+-sensitive negative regulator of ASK1-mediated signaling events.

TL;DR: The crystal structures of human ATG5 in complex with an N-terminal domain of ATG16L1 as well as an internal AIR domain of TECPR1 are described, providing new insights into the molecular details of the autophagosome maturation process, from its elongation to its fusion with a lysosome.