Takanobu Otomo

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: HSCT showed effectiveness towards brain or heart involvement, when performed before signs of brain atrophy or valvular regurgitation appear, and it is considered HSCT is worthwhile in early stages of the disease for patients with MPS II.

TL;DR: A novel role of phosphoinositide on lysosomes and an association between autophagy and neuronal disease are revealed and reveal the mechanisms underlying autophagosome–lysosome fusion process.

TL;DR: The results show the effective molecular diagnosis of ML II and III and also provide phenotypic prediction, which is the first and comprehensive report of molecular analysis for ML patients of Japanese origin.