Carlos Gorbea

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Valosin-containing protein (VCP), an AAA (ATPases associated with a variety of cellular activities) family member, is identified that co-precipitates with IκBα immune complexes and may play an important role in the proteasome-mediated degradation of Iκbα.

TL;DR: MAD2, an essential component of the mitotic checkpoint, associates with the cyclin B-ubiquitin ligase, known as the cyclosome or anaphase-promoting complex, and causes a metaphase arrest in cycling Xenopus laevis egg extracts and prevents Cyclin B proteolysis by blocking its ubiquitination, indicating that MAD2 functions as an inhibitor of the cyclOSome.

TL;DR: The screened TLR3 in patients diagnosed with enteroviral myocarditis/cardiomyopathy identified a rare variant in one patient as well as a significantly increased occurrence of a common polymorphism compared with controls, suggesting that individuals harboring these variants may have a blunted innate immune response toEnteroviral infection, leading to reduced viral clearance and an increased risk of cardiac pathology.

TL;DR: In vitro and in vivo co‐precipitation studies have revealed that the 19S regulatory components of the proteasome, Sug1 and S4, bind through amino acids (aa) 4–25 of Ad5 E1A, suggesting that AdE1A interferes with both nuclear and cytoplasmic proteasomal degradation.