Wilhelm Krek

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that the von Hippel–Lindau tumour suppressor protein pVHL negatively regulates CX CR4 expression owing to its capacity to target hypoxia-inducible factor (HIF) for degradation under normoxic conditions, resulting in HIF-dependent CXCR4 activation.

TL;DR: It is found that RBAP-1 copurifies with E2F, interacts specifically with the adenovirus E4 ORF 6/7 protein, binds specifically and directly to a known E2f DNA recognition sequence, and contains a functional tranasactivation domain.

TL;DR: It is reported that expression of p45SKP2 in untransformed fibroblasts activates DNA synthesis in cells that would otherwise growth-arrest and proposed that p45 SKP2 is important in the progression from quiescence to S phase and that the ability of p27Kip1 degradation is a key aspect of its S-phase-inducing function.

TL;DR: Cyclin A-kinase forms stable in vivo complexes with E2F-1, a growth-promoting transcription factor, which binds to the retinoblastoma gene product and is involved in the timely activation of genes whose products contribute to G1 exit and S phase traversal.