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Rajaraman Eri

Researcher at RMIT University

Publications -  134
Citations -  10703

Rajaraman Eri is an academic researcher from RMIT University. The author has contributed to research in topics: Colitis & Inflammatory bowel disease. The author has an hindex of 32, co-authored 117 publications receiving 9067 citations. Previous affiliations of Rajaraman Eri include University of Queensland & Mater Health Services.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

Chad K. Heazlewood, +16 more
- 04 Mar 2008 - 
TL;DR: It is demonstrated that mucin misfolding and ER stress initiate colitis in mice, and that ER stress-related mucin depletion could be a fundamental component of the pathogenesis of human colitis and that clinical studies combining genetics, ER stressed pathology and relevant environmental epidemiology are warranted.
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Intestinal barrier dysfunction in inflammatory bowel diseases

Michael A. McGuckin, +6 more
- 01 Jan 2009 - 
TL;DR: The components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis are reviewed.
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Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

Masayuki Fukata, +12 more
- 01 May 2005 - 
TL;DR: DSS treatment of TLR4-/- mice was associated with striking reduction in acute inflammatory cells compared with wild-type mice despite similar degrees of epithelial injury, suggesting that this is the dominant downstream pathway.
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MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.

Agampodi Promoda Perera, +9 more
- 05 Jun 2018 - 
TL;DR: Complete inhibition with MCC950 in Winnie colonic explants shows, for the first time, the contribution of inflammatory effects resulting exclusively from canonical and noncanonical NLRP3 inflammasome activation in colitis.