Sung Sik Lee

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Findings show that the Atg1 kinase acts early in autophagy by regulating the outgrowth of autophagosomal membranes.

TL;DR: A novel method for sheathless particle focusing, called "Elasto-Inertial Particle Focusing", was demonstrated in a straight microchannel and it is expected that this method can contribute to develop the miniaturized flow cytometry and microdevices for cell and particle manipulation.

TL;DR: This work identifies cytosolic pH as a second messenger for glucose that mediates activation of the PKA pathway in yeast and identifies the vacuolar ATPase (V‐ATPase), a proton pump required for the acidification of vacuoles, as a sensor of cytosol pH.

TL;DR: Findings define a conserved step in autophagy regulation in yeast and mammals and expand the known functions of LIR‐dependent Atg8 targets to include spatial regulation of the Atg1/ULK1 kinase.