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Subbiah Pugazhenthi

Researcher at Veterans Health Administration

Publications -  81
Citations -  9552

Subbiah Pugazhenthi is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: CREB & Insulin. The author has an hindex of 34, co-authored 79 publications receiving 8659 citations. Previous affiliations of Subbiah Pugazhenthi include Anschutz Medical Campus & United States Department of Veterans Affairs.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

Subbiah Pugazhenthi, +8 more
- 14 Apr 2000 - 
TL;DR: Data indicate that regulation of Bcl-2 expression by IGF-I involves a signaling cascade mediated by PI 3-kinase/PDK1/Akt/CREB, and the observation that enhanced CREB activity by Akt signaling leads to increased B cl-2 promoter activity and cell survival.
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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆

Subbiah Pugazhenthi, +3 more
- 01 May 2017 - 
TL;DR: Molecular mechanisms that link obesity, diabetes and AD, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders are discussed.
Journal ArticleDOI

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons.

Subbiah Pugazhenthi, +5 more
- 19 Aug 2011 - 
TL;DR: The findings suggest that chronic downregulation of CREB-mediated transcription results in decrease ofCREB content in the hippocampal neurons of AD brain which may contribute to exacerbation of disease progression.
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Oxidative Stress in Type 1 Diabetes

Kathryn Haskins, +8 more
- 01 Nov 2003 - 
TL;DR: It is demonstrated that treatment of prediabetic NOD mice for 2 weeks with a metalloporphyrin superoxide dismutase (SOD) mimetic results in marked reduction of oxidative stress in islets and vascular tissue and a reversal of macrophage defects.