Peter Hasselblatt

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Taking together, mutations in CTLA4 resulting inCTLA-4 haploinsufficiency or impaired ligand binding result in disrupted T and B cell homeostasis and a complex immune dysregulation syndrome.

TL;DR: It is suggested that Fra-2 has to be considered a contributing pathogenic factor of pulmonary fibrosis in humans after an unexpected profibrogenic function of Fra- 2 in transgenic mice resulted in generalized fibrosis with predominant manifestation in the lung.

TL;DR: A comprehensive TH cell profiling of circulating and intestinal lymphocytes isolated from patients with Crohn’s disease and ulcerative colitis suggests that a subpopulation of TH17 cells sharing a TH1 signature may be specifically involved in intestinal inflammation in CD and UC and argues against the controversial TH1/TH2 or TH17/Treg paradigms.

TL;DR: Hepatic STAT5/GR signaling is crucial for the maintenance of systemic lipid homeostasis and impairment of both signaling cascades causes severe metabolic liver disease and promotes spontaneous hepatic tumorigenesis.