Menno van Lookeren Campagne

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b is reported that represents a dominant component of the phagocytic system responsible for rapid clearance of C3-opsonized particles from the circulation.

TL;DR: It is demonstrated that antagonism of V EGF reduces ischemia/reperfusion-related brain edema and injury, implicating VEGF in the pathogenesis of stroke and related disorders.

TL;DR: It is demonstrated that caspase 3 activation in the presence of a common risk allele leads to accelerated degradation of ATG16L1, placing cellular stress, apoptotic stimuli and impaired autophagy in a unified pathway that predisposes to Crohn’s disease.

TL;DR: The biology of macrophage receptors for C3 fragments is reviewed and their role in the host response to pathogens is discussed and increased into the molecular basis of complement activation and recognition by their receptors.