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Luc J. W. van der Laan

Researcher at Erasmus University Rotterdam

Publications -  218
Citations -  15865

Luc J. W. van der Laan is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 45, co-authored 180 publications receiving 13032 citations. Previous affiliations of Luc J. W. van der Laan include VU University Amsterdam & Erasmus University Medical Center.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch, +22 more
- 15 Jan 2015 - 
TL;DR: Conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver opens up experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene therapy.
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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Laura Broutier, +21 more
- 13 Nov 2017 - 
TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.
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Tissue-specific mutation accumulation in human adult stem cells during life

Francis Blokzijl, +27 more
- 13 Oct 2016 - 
TL;DR: This work determines genome-wide mutation patterns in ASCs of the small intestine, colon and liver of human donors with ages ranging from 3 to 87 years by sequencing clonal organoid cultures derived from primary multipotent cells.
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Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection.

Jeroen N. Stoop, +6 more
- 01 Apr 2005 - 
TL;DR: Chronic HBV patients harbor an increased percentage of Treg in peripheral blood compared with controls, which could contribute to an inadequate immune response against the virus, leading to chronic infection.