Simone Di Paola

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that a lysosomal Ca2+ signalling mechanism controls the activities of the phosphatase calcineurin and of its substrate TFEB, a master transcriptional regulator of lysOSomal biogenesis and autophagy.

TL;DR: An update on the latest and more novel findings related to the functions of TRPMLs, with particular focus on the emerging role ofTRPML1 and lysosomal calcium signaling in autophagy are provided.