Xiu-Fen Ming

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Treatment of quiescent Swiss 3T3 fibroblasts with serum, or with the phosphatase inhibitors okadaic acid and vanadate, induced a 2- to 11-fold activation of the serine/ threonine RAC protein kinase, which is a component of a signaling pathway regulated by phosphatidylinositol 3-kinase, whose action is required for RAC-PK activation by phosphorylation.

TL;DR: It is demonstrated that Rho/ROCK pathway negatively regulates eNOS phosphorylation through inhibition of PKB, whereas it downregulates eNos expression independent of P KB.

TL;DR: Higher arginase enzymatic activity is involved in atherosclerotic endothelial dysfunction in apoE−/− mice, and Targeting vascular arginases may represent a novel therapeutic possibility for atherosclerosis.

TL;DR: The data presented here demonstrate that 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.