Thomas M. Durcan

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is evident that further insight into how PTMs regulate the PINK1-PARKIN pathway will be critical for the understanding of mitochondrial quality control.

TL;DR: It is reported here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin‐mediated mitophagy and uncovers a novel role forUSP8‐mediated deUBiquitination of K6‐linked ubiquitin conjugates from parkin in mitochondrialquality control.

TL;DR: The mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin is described, which suppresses mitophagy and describes a parkin-/PINK1-dependent mechanism that regulates the destruction of mitochondrial-ER contact sites.

TL;DR: Parkin, an E3 ubiquitin-ligase responsible for a common familial form of Parkinson's disease, is identified as a novel ataxin-3 binding partner and promoted via the autophagy pathway, raising the intriguing possibility that increased turnover of parkin may contribute to the pathogenesis of MJD and help explain some of its parkinsonian features.