Frank Lezoualc'h

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-est radiol, and some estradiol derivatives can prevent intracellular peroxide accumulation and, ultimately, the degeneration of primary neurons, clonal hippocampal cells, and cells in organotypic hippocampal slices.

TL;DR: The data suggest that changes in hippocampal GR homeostasis and regulation may render hippocampal neurons more vulnerable to oxidative stress-induced neuronal degeneration.

TL;DR: Evidence is provided for a novel molecular link between IGF-1-mediated neuroprotection and induction of NF-κB that is dependent on the PI 3-kinase pathway.

TL;DR: The presented model may help to identify possible neuronal target genes of NF-κB and to further elucidate the molecular basis of the differential sensitivity of neurons in neurodegenerative conditions associated with an increased oxidative burden, such as in Alzheimer’s disease.