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W. Haung Yu

Researcher at Columbia University

Publications -  13
Citations -  6240

W. Haung Yu is an academic researcher from Columbia University. The author has contributed to research in topics: Autophagy & Neurodegeneration. The author has an hindex of 9, co-authored 13 publications receiving 5703 citations. Previous affiliations of W. Haung Yu include Nathan Kline Institute for Psychiatric Research.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

Erin E. Congdon, +9 more
- 01 Apr 2012 - 
TL;DR: It is demonstrated that autophagy is a novel mechanism by which MB can reduce tau levels, and the use of this drug as a therapeutic agent in neurodegenerative diseases is supported.
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Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms

Emmanuel Planel, +10 more
- 12 Dec 2007 - 
TL;DR: Data indicate that insulin dysfunction induced abnormal tau hyperphosphorylation through two distinct mechanisms: one was consequent to hypothermia; the other was temperature-independent, inherent to insulin depletion, and probably caused by inhibition of phosphatase activity.
Journal ArticleDOI

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

Tara Vanderweyde, +7 more
- 13 Jun 2012 - 
TL;DR: Study of RNA-binding proteins and SG biology highlights novel pathways interacting with the pathophysiology of AD, providing potentially new avenues for identifying diseased neurons and potentially novel mechanisms regulating tau biology.
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Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.

Belen Tizon, +13 more
- 23 Mar 2010 - 
TL;DR: It is demonstrated that human CysC is neuroprotective in cultures exposed to cytotoxic challenges, including nutritional-deprivation, colchicine, staurosporine, and oxidative stress, and that modulation of CYSC expression has therapeutic implications for stroke, Alzheimer's disease, and other neurodegenerative disorders.