Jeffrey S. Isenberg

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A triphasic regulation of TSP1 mediated by a slow and prolonged release of NO that depends on ERK phosphorylation is demonstrated, suggesting that dose-dependent positive- and negative-feedback loops exist between NO and T SP1.

TL;DR: The first identified endogenous angiogenesis inhibitor, thrombospondin 1, also controls tissue perfusion, haemostasis and radiosensitivity by antagonizing NO signalling and is examined in cancer.

TL;DR: The biphasic nature of NO in cancer biology and the implications of NO-driven redox flux for modulation of tumor-stimulated angiogenesis, growth, and metastasis are discussed.

TL;DR: It is suggested that NO regulation of MMP-9 secreted from macrophages may occur chemically by reactive nitrogen species-mediated protein modification, biologically through soluble guanylyl-cyclase-dependent modulation of the M MP-9/TIMP-1 balance, or proteolytically through regulation ofMMP-1 and -13, which can cleave the prodomain of Mmp-9.