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Kuen Jer Tsai

Researcher at National Cheng Kung University

Publications -  78
Citations -  7797

Kuen Jer Tsai is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 23, co-authored 69 publications receiving 6753 citations. Previous affiliations of Kuen Jer Tsai include Academia Sinica & Southern Taiwan University of Science and Technology.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

I-Fang Wang, +7 more
- 11 Sep 2012 - 
TL;DR: It is shown that rapamycin treatment effectively rescues the learning/memory impairment of these mice at 3 mo of age, and it significantly slows down the age-dependent loss of their motor function, suggesting that autophagy activation is a potentially useful route for the therapy of neurodegenerative diseases with TDP-43 proteinopathies.
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Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U

Kuen Jer Tsai, +11 more
- 02 Aug 2010 - 
TL;DR: Direct evidence is provided that increased levels of TDP-43 protein in the forebrain is sufficient to lead to the formation of T DP-43+, ubiquitin+ NCIs and neurodegeneration.
Journal ArticleDOI

Lipids and Alzheimer's Disease.

Yu-Chia Kao, +4 more
- 22 Feb 2020 - 
TL;DR: Insight into the connection between lipids and AD is crucial to unraveling the metabolic aspects of this puzzling disease.
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Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Yu Sheng Fang, +17 more
- 12 Sep 2014 - 
TL;DR: It is demonstrated that the recombinant full-length human TDP-43 forms structurally stable, spherical oligomers that share common epitopes with an anti-amyloid oligomer-specific antibody, demonstrating interconvertibility between the amyloid species.