Ashish Jain

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This work has mapped an antioxidant response element (ARE) in the p62 promoter that is responsible for its induction by oxidative stress via NRF2 and explains how p62 contributes to activation ofNRF2 target genes in response to oxidative stress through creating a positive feedback loop.

TL;DR: It is demonstrated, using a well characterized Drosophila melanogaster malignant tumour model, that non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically in distant tissues.

TL;DR: The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion.

TL;DR: ATG8 family proteins act as scaffolds anchoring the ULK complex on autophagosomes, and the LIR motif is required for starvation-induced association of ULK1 with autophagy, in addition to the known requirements of the aromatic and hydrophobic residues of the core motif.