Zhendong Zhao

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This study shows that Sars-CoV-2 perturbs host innate immune response via both its structural and nonstructural proteins, and thus provides insights into the pathogenesis of SARS-Cov-2.

TL;DR: It is shown that EV71 inhibits anti-viral type I interferon (IFN) responses by targeting the mitochondrial anti-Viral signaling (MAVS) protein—a unique adaptor molecule activated upon retinoic acid induced gene-I and melanoma differentiation associated gene (MDA-5) viral recognition receptor signaling—upstream of type Iinterferon production.

TL;DR: The data suggested HCV inhibited the AKT-TSC-MTORC1 pathway via ER stress, resulting in autophagy, which may contribute to the establishment of the HCV-inducedAutophagy.

TL;DR: The induction of autophagy by the structural HCV core protein and subsequent endoplasmic reticular stress in Huh7 hepatoma cells and how downstream UPR molecules regulate key autophagic gene expression are reported are reported.