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Anna Pensalfini

Researcher at Nathan Kline Institute for Psychiatric Research

Publications -  34
Citations -  8881

Anna Pensalfini is an academic researcher from Nathan Kline Institute for Psychiatric Research. The author has contributed to research in topics: Amyloid & P3 peptide. The author has an hindex of 26, co-authored 31 publications receiving 7900 citations. Previous affiliations of Anna Pensalfini include University of California, Irvine & University of Florence.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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A causative link between the structure of aberrant protein oligomers and their toxicity

Silvia Campioni, +11 more
- 01 Feb 2010 - 
TL;DR: It is suggested that structural flexibility and hydrophobic exposure are primary determinants of the ability of oligomeric assemblies to cause cellular dysfunction and its consequences, such as neurodegeneration.
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Atomic view of a toxic amyloid small oligomer.

Arthur Laganowsky, +12 more
- 09 Mar 2012 - 
TL;DR: A segment of the fibril-forming protein αB crystalline, which forms an oligomeric complex exhibiting properties of other amyloid oligomers: β-sheet–rich structure, cytotoxicity, and recognition by an oligomers-specific antibody is identified.
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Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

Rakez Kayed, +7 more
- 13 Feb 2009 - 
TL;DR: The preparation of relatively homogeneous preparations of APFs and an antiserum selective for APFs (αAPF) compared with prefibrillar oligomers (PFOs) and fibrils is reported, suggesting that lipid vesicles catalyze the conversion of PFOs into APFs.
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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.

Jennifer L. Tomic, +3 more
- 01 Sep 2009 - 
TL;DR: It is found that the levels of soluble fibrillar oligomers detected by OC antibody are significantly elevated in multiple brain regions of AD patients, suggesting that they precede dementia in AD and may be a new target for diagnostic and therapeutic development.