Cinzia Lanzi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The isolation and characterization of one of the thyroid TRK oncogenes, designated TRK-T1 is described, which is created by an intrachromosomal rearrangement that juxtaposes the 5' end of the TPR gene to the TRK tyrosine kinase domain.

TL;DR: Results indicate that MGR3 is directed against a determinant located in the p 185HER2 ligand binding site and may compete with the p185HER2ligand, but is incapable of inducing a complete mitotic signal.

TL;DR: The antitumor efficacy and oral bioavailability of RPI-1 support its therapeutic potential and Ret oncoproteins represent exploitable targets for therapeutic intervention in MEN2A-associated medullary thyroid carcinoma.

TL;DR: In this article, the authors explored the molecular mechanisms involved in primary resistance to PLX4032 and investigated its effects on cell proliferation and signaling in a panel of 27 genetically characterized patient-derived melanoma cell lines.