Yan G. Zhao

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Dysfunction of autophagosome maturation is associated with various human diseases, including neurodegenerative diseases, Vici syndrome, cancer, and lysosomal storage disorders, and understanding the molecular mechanisms underlying autophagy will provide new insights into the pathogenesis and treatment of these diseases.

TL;DR: The coordinated actions of membrane-bound and membraneless organelles ensure spatiotemporal control of various cellular functions.

TL;DR: It is demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts and it is revealed that VMP1 modulates SERCA activity to control ER contacts.

TL;DR: This study reveals that VAPs directly interact with multiple ATG proteins, thereby contributing to ER/IM contact formation for autophagosome biogenesis.