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Karine G. Le Roch

Researcher at University of California, Riverside

Publications -  145
Citations -  12506

Karine G. Le Roch is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 45, co-authored 127 publications receiving 11298 citations. Previous affiliations of Karine G. Le Roch include University of the South Pacific & Genomics Institute of the Novartis Research Foundation.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle

Karine G. Le Roch, +11 more
- 12 Sep 2003 - 
TL;DR: A high-density oligonucleotide array is used to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle and finds genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.
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Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

Karine G. Le Roch, +11 more
- 01 Nov 2004 - 
TL;DR: Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
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The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.

Jason A. Young, +8 more
- 01 Sep 2005 - 
TL;DR: Light is shed on the components of molecular mechanisms underlying parasite sexual development and other areas of malarial parasite biology by applying a novel knowledge-based data-mining algorithm termed ontology-based pattern identification (OPI).
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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

Nobutaka Kato, +27 more
- 01 Jun 2008 - 
TL;DR: A targeted gene-disruption approach demonstrated that pfcdpk1 seems to be essential for parasite viability, and an in vitro biochemical screen using recombinant PfCDPK1 against a library of 20,000 compounds resulted in the identification of a series of structurally related 2,6,9-trisubstituted purines.