Edward D. Plowey

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Results indicate an active role for autophagy in neurite remodeling induced by pathogenic mutation of LRRK2, implicating MAPK/ERK‐related signaling.

TL;DR: A brain macrophage transplantation system is created to disentangle how environment and ontogeny specify microglial identity, and it is found that donor cells extensively engraft in the CNS of microglia-deficient mice, and even after exposure to a cell culture environment,microglia fully regain their identity when returned to the CNS.

TL;DR: Several molecular cell biological and imaging methods to study autophagy and mitophagy in neuritic and somatic compartments of differentiated neuronal cell lines and primary neuron cultures are highlighted, using protocols developed in toxic and genetic models of parkinsonian neurodegeneration.

TL;DR: This first-in-human study demonstrates the feasibility and safety of antibody based imaging for CE glioblastomas by determining if therapeutic antibodies could be repurposed for intraoperative imaging during resection.