Maria Rosaria Torrisi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that activation of monocytes results in the redistribution of HMGB1 from the nucleus to cytoplasmic organelles, which display ultrastructural features of endolysosomes, which means that in monocytes, non‐classical secretion can occur through vescicle compartments that are at least partially distinct.

TL;DR: The evidence is provided for a "leaderless" secretory route that uses regulated exocytosis of preterminal endocytic vesicles to transport cytosolic IL-1beta out of the cell.

TL;DR: The molecular mechanism(s) undergoing IL-1 beta processing and release in human monocytes are analyzed to provide a unifying model for the regulated secretion of the cytokine and demonstrate that K(+) efflux is responsible for phosphatidylcholine-specific phospholipase C induction, which in turn allows the rise in intracellular free calcium concentration required for activation of phospholIPase A(2).

TL;DR: It is hypothesized that exosome-mediated transfer of functional pro-metastatic factors by LMP1-positive NPC cells to surrounding tumor cells promotes cancer progression and is provided evidence that HIF1α itself participates in exosomes-mediated pro- Metastatic effects in recipient cells.