Barry Yedvobnick

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is concluded that DNA sequences belonging to the Notch locus have been cloned and that the 10.5-kb poly(A)+ RNA is essential for wild-type Notch function.

TL;DR: Results indicate that Mam is an essential component of the transcriptional apparatus of Notch signaling, and expresses a human sequence related to Drosophila Mam that stabilizes and participates in the DNA binding complex of the intracellular domain of human Notch1 and a CSL protein.

TL;DR: In this paper, the authors constructed truncated versions of the Drosophila mastermind (mam) protein that elicit dominant phenotypes when expressed in imaginal tissues under GAL4-UAS regulation and found that truncated Mam protein results in failure of lateral inhibition within proneural clusters and perturbations in cell fate specification within the sensory organ precursor cell lineage.