Faraj Terro

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Different types of post-translational modifications of tau including phosphorylation, glycosylation, glycation, prolyl-isomerization, cleavage or truncation, nitration, polyamination, ubiquitination, sumoylation, oxidation and aggregation are reviewed with a particular interest towards their relevance in AD.

TL;DR: It is reported that in primary cultured neurons from cortices of transgenic mice, overexpression of mutated PS1 but not PS1 wild‐type (wt) enhanced spontaneous neuronal apoptosis that involved oxidative stress and caspase activation, indicating that PS1 interferes with a specific apoptotic pathway that results from a dysfunction of the ER‐Golgi compartment.

TL;DR: Findings demonstrate that in vivo, GSK‐3β kinase activation and nuclear translocation are early stress signals of neuronal apoptosis.