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Ivan Topisirovic

Researcher at McGill University

Publications -  146
Citations -  16418

Ivan Topisirovic is an academic researcher from McGill University. The author has contributed to research in topics: EIF4E & Translation (biology). The author has an hindex of 53, co-authored 137 publications receiving 13889 citations. Previous affiliations of Ivan Topisirovic include Jewish General Hospital & Samsung Medical Center.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Ryan J.O. Dowling, +12 more
- 28 May 2010 - 
TL;DR: Control of cell size and cell cycle progression appear to be independent in mammalian cells, whereas in lower eukaryotes, 4E-BPs influence both cell growth and proliferation.
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Targeting the translation machinery in cancer

Mamatha Bhat, +5 more
- 01 Apr 2015 - 
TL;DR: The role of translation in cancer is discussed, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and an overview of recent efforts aiming to 'translate' these results to the clinic is provided.
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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Masahiro Morita, +18 more
- 05 Nov 2013 - 
TL;DR: It is demonstrated that mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs).
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Dissecting the role of mTOR: lessons from mTOR inhibitors.

Ryan J.O. Dowling, +3 more
- 01 Mar 2010 - 
TL;DR: The molecular underpinnings of the action of rapamycin and novel active-site mTOR inhibitors are reviewed as well as potential advantages and caveats associated with the use of these drugs in the treatment of cancer.