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Puran Singh Sijwali

Researcher at Centre for Cellular and Molecular Biology

Publications -  56
Citations -  7825

Puran Singh Sijwali is an academic researcher from Centre for Cellular and Molecular Biology. The author has contributed to research in topics: Plasmodium falciparum & Cysteine protease. The author has an hindex of 24, co-authored 50 publications receiving 7169 citations. Previous affiliations of Puran Singh Sijwali include Academy of Scientific and Innovative Research & University of California, San Francisco.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.

Bhaskar R. Shenai, +3 more
- 15 Sep 2000 - 
TL;DR: The results suggest thatfalcipain-2 can initiate cleavage of native hemoglobin in the P. falciparum food vacuole, that, following initial cleavages, the protease plays a key role in rapidly hydrolyzing globin fragments, and that a drug discovery effort targeted at this protease is appropriate.
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Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

Puran Singh Sijwali, +1 more
- 30 Mar 2004 - 
TL;DR: A specific function is assigned for falcipain-2, the hydrolysis of hemoglobin in trophozoites, which highlights the cooperative action of cysteine and aspartic proteases in hemoglobin degradation by malaria parasites.
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Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3.

Puran Singh Sijwali, +4 more
- 01 Dec 2001 - 
TL;DR: Falcipain-3 is a second P. falciparum haemoglobinase that is particularly suited for the hydrolysis of native haemochemistry in the acidic food vacuole, and may offer optimized hydroolysis of both native ha Hemoglobin and globin peptides.
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Cysteine proteases of malaria parasites: Targets for chemotherapy

Philip J. Rosenthal, +3 more
- 31 Jul 2002 - 
TL;DR: A number of small molecule cysteine protease inhibitors blocked parasite hemoglobin hydrolysis and development, and inhibitory effects against parasites generally correlated with inhibition of falcipain-2, and some compounds also cured mice infected with otherwise lethal malaria infections.