Santiago Ambrosio

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the involvement of the immune system in Parkinson's disease was assessed using the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients, and they found a numeric decrease in helper T cells (higher in CD4+CD45RA(+) than in CD+CD29(+)) and B cells, and a rise in activated, CD4(+)CD25(+) lymphocytes that was correlated with lymphocyte depletion.

TL;DR: The present results show that the microdialysis technique can be used to determine levels of purines in the extracellular fluid of defined brain regions in awake animals and that adenosine levels can be altered in vivo by inhibitors of adenoine transport and adenosines deaminase.

TL;DR: The results show that nonapoptotic death pathways are triggered by dopamine, leading to autophagy, and should be taken into account in the search for strategies to protect dopaminergic neurons from degeneration.

TL;DR: Results show that MAPKs are differentially regulated in neurons with α-synuclein-related inclusions and in neuron with abnormal tau deposits in DLB, which suggest a pathogenesis of brain stem and cortical LBs in LB diseases.