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José M. Cuezva

Researcher at Spanish National Research Council

Publications -  136
Citations -  11879

José M. Cuezva is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Mitochondrion & ATP synthase. The author has an hindex of 47, co-authored 128 publications receiving 10714 citations. Previous affiliations of José M. Cuezva include Autonomous University of Madrid & Carlos III Health Institute.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal Article

The Bioenergetic Signature of Cancer: A Marker of Tumor Progression

José M. Cuezva, +9 more
- 15 Nov 2002 - 
TL;DR: The metabolic state of the cell, as defined by a bioenergetic mitochondrial index relative to the cellular glycolytic potential, provides a signature of carcinogenesis of prognostic value in assessing the progression of colorectal carcinomas.
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Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

Baskaran Govindarajan, +24 more
- 01 Mar 2007 - 
TL;DR: It is demonstrated that Akt was associated with malignant transformation of melanoma through at least 2 mechanisms, and may stabilize cells with extensive mitochondrial DNA mutation, which can generate ROS, and can induce expression of the ROS-generating enzyme NOX4.
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The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

Laura Formentini, +3 more
- 30 Mar 2012 - 
TL;DR: It is demonstrated that IF1 overexpression in colon cancer cells triggers mitochondrial hyperpolarization and the subsequent production of superoxide radical, a reactive oxygen species (ROS), which provides evidence linking the activity of a mitochondrial protein with retrograde signaling to the nucleus to promote cellular proliferation and survival.
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Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer

Antonio Isidoro, +7 more
- 15 Feb 2004 - 
TL;DR: Overall, the relative expression of beta-F1-ATPase was significantly reduced in breast and gastric adenocarcinomas, as well as in squamous oesophageal and lung carcinomas, strongly suggesting that alteration of the bioenergetic function of mitochondria is a hallmark of these types of cancer.