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Usha P. Andley

Researcher at Washington University in St. Louis

Publications -  88
Citations -  9100

Usha P. Andley is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Crystallin & Lens protein. The author has an hindex of 34, co-authored 87 publications receiving 8378 citations. Previous affiliations of Usha P. Andley include Massachusetts Eye and Ear Infirmary.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Crystallins in the eye: Function and pathology.

Usha P. Andley
- 01 Jan 2007 - 
TL;DR: Recent work with lens epithelial cells from alphaA- and alphaB-crystallin knockout mice suggests that crystallins have important cellular functions in the lens epithelium and not just the lens fiber cells as previously thought.
Journal Article

Propagation and Immortalization of Human Lens Epithelial Cells in Culture

Usha P. Andley, +3 more
- 01 Jun 1994 - 
TL;DR: This report constitutes the first successful immortalization of human lens epithelial cells, which may provide an important human cell line specific to in vivo human Lens epithelial cell physiology and would be of interest in establishing a human model to study lens cell differentiation and the etiology of cataract.
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Pharmacological chaperone for α-crystallin partially restores transparency in cataract models

Leah N. Makley, +12 more
- 06 Nov 2015 - 
TL;DR: The most promising compound improved lens transparency in the R49C cryAA and R120G cryAB mouse models of hereditary cataract and partially restored protein solubility in the lenses of aged mice in vivo and in human lenses ex vivo, suggesting an approach to treating cataracts by stabilizing α-crystallins.
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Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q.

Donna S. Mackay, +2 more
- 01 Oct 2003 - 
TL;DR: This study has identified the first dominant cataract mutation in CRYAA located outside the phylogenetically conserved ‘alpha-crystallin core domain’ of the sHSP family.