Christian Kuhn

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is reported that FGF23 exclusively activates FGFR4 on cardiac myocytes to stimulate phospholipase Cγ/calcineurin/nuclear factor of activated T cell signaling and promotes LVH by activatingFGFR4, thereby establishing FGFR 4 as a pharmacological target for reducing cardiovascular risk in CKD.

TL;DR: A systematic view on the currently known Z-disc components and the functional significance of the Z- Disc as an interface between biomechanical sensing and signalling in cardiac and skeletal muscle functions and diseases is provided.

TL;DR: Findings show important roles for calsarcins as modulators of calcineurin signaling and the transmission of a specific subset of stress signals leading to cardiac remodeling in vivo.

TL;DR: In this paper, a real-time RT-PCR approach using fluorescent-labeled hybridization probes (LightCycler technology) was used to determine whether BCR-ABL transcript levels can predict chromosomal response.