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Balindiwe J.N. Sishi

Researcher at Stellenbosch University

Publications -  17
Citations -  5780

Balindiwe J.N. Sishi is an academic researcher from Stellenbosch University. The author has contributed to research in topics: Autophagy & Cardiotoxicity. The author has an hindex of 11, co-authored 17 publications receiving 5270 citations.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Diet‐induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

TL;DR: It is proposed that dyslipidaemia may be a mechanism for the activation of inflammatory/stress‐activated signalling pathways in obesity and type II diabetes, which will lead to apoptosis and atrophy in skeletal muscle.
Journal ArticleDOI

Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity

TL;DR: Results strongly indicate that the co-treatment strategy with rapamycin can attenuate the cardiotoxic effects of DXR in a tumour-bearing mouse model.
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Tumor necrosis factor alpha (TNF-α) inactivates the PI3-kinase/PKB pathway and induces atrophy and apoptosis in L6 myotubes.

TL;DR: Observations suggest that TNF-α induces muscle proteolysis in a dose-dependent manner via various signal transduction pathways through certain MAPKs that are activated.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 -